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关键词： chemistry   medical research  

ISBN: (数字)9780080583785 ISBN: (纸本)9780120405343

摘要： Annual Reports in Medicinal Chemistry continues to strive to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies. Volume 34 retains the familiar format of previous volumes, this year with 33 chapters. Sections I-IV are disease-oriented and generally report on specific medicinal agents with updates from Volume 33 on antithrombotics, neurokinin receptor antagonists, anticoagualants, and new antibacterials. As in past volumes, annual updates have been limited to only the most active areas of research in favor of specifically focused and mechanistically oriented chapters, where the objective is to provide the reader with the most important new results in a particular field. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design as well as the critical interfaces among these disciplines. This volume concludes with To Market, To Market--a chapter on NCE and NBE introductions worldwide in 1998, a chapter on pharmagenomics, and finally one on malaria as a third world disease in need of a first world drug development.

关键词： biochemistry   pharmaceutical technology  

ISBN: (数字)9780080862842 ISBN: (纸本)9780444500908

摘要： Progress in Medicinal Chemistry

关键词： 汉方方剂   ODC   生姜泻心汤   小鼠皮肤   抗促癌   温清饮  

摘要： 以小鼠耳廓肿胀、皮肤二阶段致癌以及皮肤鸟氨酸脱羧酶(ODC)诱导试验,探讨了配伍黄芩的汉方方剂(温清饮、三黄泻心汤、生姜泻心汤、干姜黄连黄芩人参汤、黄芩汤)以及单味黄芩的抗促癌作用。

关键词： cellular biology  

ISBN: (数字)9780080526775 ISBN: (纸本)9780762305933

摘要： Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

关键词： medical toxicology   chemistry  

ISBN: (数字)9780080526379 ISBN: (纸本)9780762300648

摘要： Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

关键词： 院士   沈阳药科大学   药学博士   学位   化学成分   人参   化学组成   补气药   东京大学   天然药物化学   中共党员   中国共产党党员  

摘要： 姚新生，１９３４年１０月生于上海市，汉族，中共党员。１９５５年毕业于东北药学院并留校任教。１９８１年赴日本东京大学留学，１９８３年获药学博士学位。现为沈阳药科大学博士生导师、校长、党委副书记、中国工程院院士。姚新生院士是我国著名的天然药物化学家，在天...

关键词： 天然药物化学   李铣  

摘要： 李铣教授１９４０年生于辽宁省辽阳市，１９６１年毕业于沈阳药科大学药学系，并留校从事天然药物化学研究和教学工作。１９７１年他在中国医学科学院药物研究所进修，在黄量教授指导下进行天然产物结构研究。１９８１至１９８３年在美国斯坦福大学化学系做访问学者，１９...

关键词： 卤代喹啉   NMR   化学位移   药物化学  

摘要： 报道了１１种新的３卤代喹啉的１３ＣＮＭＲ谱．应用１３ＣＮＭＲ等谱确定了这１１种新化合物的分子结构，并对全部谱峰进行了归属，初步探讨了分子结构对１３ＣＮＭＲ化学位移的影响．

关键词： 药物化学   学科:普及读物  

ISBN: (纸本)7535526349

摘要： 早期的药物发现和研究与化学学科的发展有密切的关系。随着各学科的发展，当今的药学已是化学、生命科学、计算机化学等多学科的综合体现。为了反映当今药学的状况，提高读者对药物的使用和对药物在治疗疾病中的重要性的认识，本书选择、介绍了药物的一般知识、麻醉药、抗微生物药、抗生素、抗肿瘤药和药和的结构与生物活性关系等六个方面的内容。书中对一些著名这者的成功业绩和他们的思考方法也作了一些介绍，希望能让读者在增加药学知识的同时在思维方法上也有所启发。

关键词： 吡酮   药物合成   药物化学  

摘要： 吡酮酸（俗称喹诺酮）类抗菌药已成为一大类广泛用于临床的广谱、高效、低毒的抗感染化疗药物。为推动我国在该领域的研究开发工作，我们曾对吡酮酸化学研究进行过小结［１］。近年来吡酮酸类抗感染药物仍是被广泛关注的热点领域之一，并继续获得快速发展，作为上述小结的...