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关键词： 医学期刊   临床研究   伦理委员会   知情同意   伦理审查  

摘要： 对《中华微生物学和免疫学杂志》2005—2016年刊出的457篇临床研究论文的伦理批准和知情同意情况进行统计分析。结果发现,获得伦理委员会批准的总的比例为17.3%,获得知情同意总的比例为26.0%,既获得伦理委员会批准又获得知情同意的论文比例为12.9%。提出加强医学研究的伦理审查、提高医学论文伦理水平的建议。

关键词： 数字出版   微生物学   免疫学   稿件   学术论文   论文发表   科研成果   合作协议  

摘要： 为缩短学术论文发表周期,提高学术论文的时效性和影响力,争取创新性科研成果的首发权,《微生物学免疫学进展》于2012年1月与中国知网（CNKI）签订了《学术期刊优先数字出版合作协议》。

关键词： sanguinarine   immunological responses   microbial counts   jejunal morphology   serum biochemical parameters   crude protein   laying hens  

摘要： This study was carried out to assess the effects of different levels of sanguinarine on antioxidant indices, immunological responses, serum biochemical parameters, ileal microbial counts and jejunal morphology of laying hens fed on diets with different levels of crude protein (CP). A total of 180 laying hens were subjected into nine dietary treatments with four cages of five birds each. Experimental treatments consisted of three levels of CP (85.0, 92.5 and 100% of Hy-Line W36 manual recommendation) and three levels of sanguinarine (0.00, 3.75 and 7.50mg/kg) as a 3x3 factorial arrangement of laying hens which fed during a 70-day feeding trial. The invitro study showed that sanguinarine exhibited sevenfold and threefold decreased antioxidant activities to inhibit 2-2-diphenyl-1-picric hydrazyl free radical as well as ferric ion reducing rather than butylated hydroxyl toluene. Although using the decremental levels of CP caused the increase in heterophil-to-lymphocyte ratio (p<0.01), dietary administration of sanguinarine could suppress the serum cholesterol and malondialdehyde concentrations as well as heterophil-to-lymphocyte ratio (p<0.05). Additionally, decreasing CP content resulted in the decreased percentage of albumin (p<0.05);however, it had no negative effects on humoral immunity. Nonetheless, feeding of at least 3.75mg/kg sanguinarine led to the remarkable increases in serum gamma globulin concentration (p<0.01) and secondary (p<0.05) antibody titres against sheep red blood cells. Moreover, a decline in dietary CP content led to higher villi height and crypt depth (p<0.05;p<0.001) and consequently decreased villi height-to-crypt depth ratio (p<0.001) than the optimum level (100% CP). In spite of the effects of sanguinarine on the suppression of Escherichia coli and Salmonella counts (p<0.05), it markedly enhanced villi height-to-crypt depth ratio as well as lamina propria lymphatic follicles extent, simultaneously (p<0.001). Therefore, in spite of the detrim

关键词： butyrate-producing bacteria   dietary fiber   fermented vegetable   regulatory T cells  

摘要： We aimed to investigate the effects of feeding fermented Brassica rapa L. on ecological and immunological changes in the mouse gut using in vitro cultivation tests and in vivo experiments in normal mice. In the preliminary in vitro study, two B. rapa L. products from different fermentation periods (one d [SF] or six months [LF]) were evaluated along with non-fermented vegetables (NF). Among the components of each product, the insoluble fraction resulted in the most prominent change such as a relative increase in butyrate production during a cultivation inoculated with mouse cecum contents. Based on this result, the boiled water-insoluble fractions of B. rapa L. (SF, LF, and NF samples) were selected as test materials for the subsequent in vivo experiment. Male C57BL/6J mice were divided into four groups and fed either a control diet (CON) or control diet plus one of the insoluble fractions for two weeks. The NF and LF groups had higher relative populations of Faecalibacterium prausnitzii than the CON group. Therefore, colonic butyrate concentrations were higher in the NF and LF groups than in the CON group. The oral administration of B. rapa L. extract induced immune regulatory effects, even when mice were fed NF and SF, but not LF, as assessed by an increase in regulatory T cell numbers. Our results indicate that feeding a purified insoluble fraction from B. rapa L. affects enteric short-chain fatty acid production and immunological responses in the mouse gut in a similar manner, regardless of the fermentation status.

关键词： 书写规范   微生物学   免疫学   杂志   中华   信息交换   表示法   数据元  

摘要： 1．根据GB／T7408-94《数据元和交换格式信息交换日期和时间表示法》，由特定起点与终点定界的时间段的表示，起点与终点之间以一字线为分隔符，而不再用波纹线。示例如下：2001-2004年，而不再表示为2001-2004年，但“-”可以用“至”取代。

关键词： 免疫学专业   中华医学会   微生物学   杂志   稿约   科研人员   学术期刊   卫生防疫  

摘要： 《中华微生物学和免疫学杂志》为中华医学会主办的微生物学和免疫学专业学术期刊，以该学科的科研人员、教师、研究生以及有关的中、高级卫生防疫、检验工作者为主要读者对象，报道该领域领先的科研成果和实践经验的论著、简报。一、本刊欢迎论著、论著摘要、技术交流、会议（座谈）纪要、书评、国内外学术动态等稿件。

关键词： 维普数据库   中华预防医学会   美国化学文摘   国内统一刊号   中国知网   国际标准刊号   中国学术   免疫学   中国生物技术   发行范围  

摘要： 《微生物学免疫学进展》1973年创刊,系中华预防医学会系列杂志,由中国生物技术股份有限公司旗下的兰州生物制品研究所有限责任公司主办的国家级科技期刊。系中国科技论文统计源期刊（中国科技核心期刊）,中国学术期刊综合评价数据库（CAJCED）统计源期刊,《中国学术期刊影响因子年报》统计源期刊,中国期刊全文数据库（CJFD）收录期刊,美国化学文摘（CA）收录期刊,中国知网、万方数据库、维普数据库全文收录期刊。双月刊,全年6期,国内外公开发行。国际标准刊号为ISSN 1005—5673,国内统一刊号为CN62-1120/R。

关键词： 书写规范   微生物学   免疫学   杂志   中华   信息交换   表示法   数据元  

摘要： 1．根据GB／T7408—94《数据元和交换格式信息交换日期和时间表示法》，由特定起点与终点定界的时间段的表示，起点与终点之间以一字线为分隔符，而不再用波纹线。示例如下：

关键词： Embryogenesis• Mucosal immunology  

摘要： The comparison of the immunological state of pregnancy to an immunosuppressed host-graft model continues to lead research and clinical practice to ill-defined approaches. This Review discusses recent evidence that supports the idea that immunological responses at the receptive maternal-fetal interface are not simply suppressed but are instead highly dynamic. We discuss the crucial role of trophoblast cells in shaping not only the way in which immune cells respond to the invading blastocyst but also how they collectively react to external stimuli. We also discuss the role of the microbiota in promoting a tolerogenic maternal immune system and highlight how subclinical viral infections can disrupt this status quo, leading to pregnancy complications.