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关键词： 国际药学   相关学科   临床药理学   酒精中毒   呼吸道疾病   在美国   师举   瑞士巴塞尔   斯举   加的夫  

摘要： 1.3月21日～23日在美国旧金山举行美国临床药理学和治疗学协会第91届年会。 2.5月16日在英国伦敦举行了化学工业学会关于治疗呼吸道疾病的药物会议。 3.6月10日～15日在西柏林举行了关于预防和治疗酒精中毒及耐药性的国际研讨会。 4.6月26日～29日在捷克斯洛克伐举行了小儿临床药理学会议。 5.

关键词： 临床药理学   理论深度   李家泰   丁光生   药物合理使用   方圻   陶萍   各论   人民卫生出版社   医药院校师生  

摘要： 由李家泰教授主编,江文德,陶萍、桑国卫、于毓文四位教授副主编,丁光生教授、方圻教授与杨藻宸教授主审的《临床药理学》即将由人民卫生出版社出版。本书分总、各论两篇,全书55章,约120万字。将在1990年12月份出书。总论内容为临床药理学的基本理论与研究方法,各论包括常用药物的治疗学总论及各类药物合理使用原则与方法。在叙述上力求深入浅出,既有理论深度,又有实际应用价值,附有参考文献及较实用的附录,是国内目前最详尽而丰富的权威著作。

关键词： 情报工作者   医药品   药事法   合理用药   资格制度   情报活动   临床药理学   临床试验   医药企业   医药代表  

摘要： 医药情报工作者的任务是什么?就是作为公司的代表当面对医务工作者进行制品的适当使用和普及促进活动。医药品的特性是与人类的生命、健康有密切的关系,其社会性、公共性极高;而且医药品本身必定具备一定的有效物质和疗效,故医药情报工作者为了使医生对每一个病人都能做到合理用药,进行充分的医药情报工作是必要的,俾使医药品迅速普及推广。为此,医药情报工作者不仅要学习掌握一定的知识和技能,而且要基于职业道德进行工作。1979年日本在改正药事法的过程中对医药情报工作者的资格制度进行了讨论,为此。

关键词： .offered   consultations   Didactic   fourth-year  

摘要： A 1-month elective course in clinical pharmacology in primary care has been developed and is offered six times a year for fourth-year medical students. The major course objective is to teach the student to apply the principles of rational therapeutics in the routine practice of primary care. The faculty includes clinical pharmacists and primary care physicians from the Department of Family Medicine. Two students each month rotate through a combined didactic and experiential curriculum oriented toward the rational selection and monitoring of drugs in inpatient and outpatient settings. Students interact daily with faculty members and have ample opportunity to evaluate drug therapy regimens and assist in designing new therapeutic strategies. Students are evaluated on their performance in conferences, written consultations, and oral case challenges. Evaluations by students indicate that this elective is a valuable educational experience.

关键词： .Indocyanine   atenolol   ICG   Hypertensive Subjects   dilevalol  

摘要： Dilevalol (100 mg) or atenolol (50 mg) was given orally in 13 subjects with essential hypertension. Two trials were done by a single-blind, crossover design with an interval of 6 days. Blood samples for drug concentrations were taken for a period of 24 hours after dosage. A retained percentage of indocyanine green dye at 15 minute (ICG R15) reflecting hepatic function and a creatinine clearance (CLCR) reflecting renal function were determined in each subject during observation period. A significant correlation was observed between the ICG R15 and the area under the plasma concentration-time curve (AUC) of dilevalol, while there was no significant correlation between the CLCR and any pharmacokinetic parameter of the agent. In contrast to dilevalol, significant correlations were observed between the CLCR and AUC or elimination half-life of atenolol. However, there was no significant correlation between the ICG R15 and any pharmacokinetic parameter of atenolol. These data indicate that the disposition of dilevalol is influenced by hepatic rather than by renal function while that of atenolol is altered by renal function.

关键词： .Mild   hypotensive   maximal   TID   nilvadipine  

摘要： Eighty-four patients with diastolic blood pressure ranging from 100-115 mm Hg were randomized into a multicenter, parallel, double-blind, placebo-controlled, dose response study with nilvadipine (6 mg, 8 mg, 10 mg tid for 28 days). The hypotensive response pattern to nivadipine was similar with all three doses although duration of response was dose dependent. Maximal decreases in diastolic blood pressure occurred at 1 hour when assessed on days 1 and 15 (16.0, 17.4, and 15.8 mm Hg, vs 17.2, 18.7, and 17.5 mm Hg, respectively). The hypotensive effect remained significant compared to placebo for at least 4 hours after dosing. The increase in heart rate associated with the maximal hypotensive response was minimal and not clinically significant (day 1: 7.6, 5.2, and 4.0 beats/min 6, 8, and 10 mg/ day 15: 4.0, 5.1, 2.6 beats/min with 6, 8, 9, and 10 mg, respectively). Finally, a correlation between plasma drug concentrations and nilvadipine-induced hypotensive response was observed (r = 0.48). Black and white hypertensive patients had similar hypotensive responses. Plasma nilvadipine concentrations on day 15 were similar to those on day 1 suggesting no accumulation of drug with a tid regimen. The most common drug related side effect was headache;less frequently seen were dizziness, edema, palpitations, and abdominal pain. Nilvadipine was well tolerated (only three patients were discontinued due to side effects). The efficacy, lack of tachycardia, and side effect profile observed in this study suggest that nilvadipine may be an important addition to the treatment of hypertension.

关键词： 临床药理学   卫生部   药理基地  

关键词： 临床药理学   合理用药