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关键词： cannabis (plant)   marihuana   hyperemesis gravidarum   signs and symptoms   digestive   hospital admission   diagnostic imaging  

关键词： Parameter identification   Discrete memristor   Chaotic map   Differential evolution algorithm   Return maps   Coexisting attractors  

摘要： Since the concept of discrete memristor was proposed, more and more scholars began to study this topic. At present, most of works on the discrete memristor are devoted to the mathematical modeling and digital circuit implementation, but the research on its synchronization control has not received much attention. This paper focuses on the parameter identification for the discrete memristive chaotic map, and a modified intelligent optimization algorithm named adaptive differential evolution algorithm is proposed. To deal with the complex behaviors of hyperchaos and coexisting attractors of the considered discrete memristive chaotic maps, the identification objective function adopts two special parts: time sequences and return maps. Numerical simulations demonstrate that the proposed algorithm has the best performance among six existing algorithms, and it can still accurately identify the parameters of the original system under noise interference.

关键词： Epstein-Barr virus   IgG antibody array   LMP1/2   EBNA protein  

摘要： Background: Epstein-Barr virus (EBV) infection contributes to cancers in a fraction of seropositive individuals, but much remains to be learned about variation in EBV-directed humoral immunity in cancer-free adults. Methods: A protein microarray was used to probe serum from 175 Taiwanese and 141 Northern European adults for immunoglobulin G (IgG) antibody responses to 115 different peptide sequences, representing protein segments or protein variants, from 45 EBV proteins. It was posited that this antibody-based approach could identify EBV peptide sequences representing immunodominant regions relevant for B-cell immunity. Results: Analyses of 45 EBV proteins with multiple protein segments or variants printed on the array identified eight EBV peptide sequences that appear to play a role in immunogenicity. This included: (1) three proteins with segments/regions associated with IgG reactivity (BALF5, LMP1, LMP2A);and (2) five proteins with sequence variants/amino acid changes associated with IgG reactivity (BDLF4, EBNA3A, EBNA3B, EBNA-LP, LF1). Conclusion: This examination of IgG antibody responses against 115 EBV peptide sequences in 316 cancer-free adults represents an important step toward identifying specific EBV protein sequences that play a role in generating B-cell immunity in humans. (C) 2021 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

关键词： chronic hypertension   chronic kidney disease   differential diagnosis of preeclampsia   preeclampsia   pregnancy   sFlt-1/PlGF  

摘要： The definition of preeclampsia is changing. However, with the addition of organ symptoms to the presence of hypertension in pregnancy instead of relying only on proteinuria, a more precise detection of women at risk of preeclampsia-associated adverse events has not been achieved. Instead, under the new definitions of the American College of Obstetricians and Gynecologists and of the International Society for the Study of Hypertension in Pregnancy, more women are classified as preeclamptic, with a tendency to milder disease. Furthermore, angiogenic and antiangiogenic factors have emerged as essential tools for predicting and diagnosing preeclampsia at high accuracies. Next to being rooted in the pathophysiology of the disease, they have been proven to be reliable tools for predicting and diagnosing the disease. In addition, 2 cutoffs have been evaluated for the clinical setting. As shown in the Prediction of Short-Term Outcome in Pregnant Women With Suspected Preeclampsia Study, at the soluble fms-like tyrosine kinase-1–to–placental growth factor ratio cutoff of 38, a preeclampsia can be ruled out for 1 week with a negative predictive value of 99.3% (95% confidence interval, 97.9–99.9) and ruled in with a positive predictive value of 36.7% (95% confidence interval, 28.4–45.7). The diagnostic cutoff of 85 has been shown to accurately identify women with preeclampsia, with a sensitivity of up to 88% and a specificity of 99.5%. In this review, we highlight the central role of angiogenic and antiangiogenic factors in the differential diagnosis of women presenting at high risk of the disease, such as patients with chronic hypertension or chronic kidney disease. We will focus on their ability to predict preeclampsia-associated adverse fetal and maternal outcomes. This is only possible when critically reviewing the evolution of the definition of “preeclampsia.” We show how changes in this definition shape our clinical picture of the condition and how angiogenic and antiangi

关键词： castration-resistant prostate cancer   complete blood count   docetaxel   neutrophil-lymphocyte ratio   systemic immune-inflammation index  

摘要： There are multiple reports on the value of complete blood count (CBC)-related parameters on prognosis in docetaxel-treated castration-resistant prostate cancer (CRPC) patients before the emergence of androgen receptor pathway inhibitors (ARPIs). We investigated the prognostic significance of CBC-related parameters in docetaxel-treated CRPC patients. Patients treated with docetaxel chemotherapy for CRPC between 2008 and 2018 were included. We analyzed the relevance of CBC-related parameters to oncological prognosis in docetaxel chemotherapy, associated with prior use of novel ARPIs. Among 144 Japanese men treated with docetaxel, 49 men (34.0%) had already received ARPI therapy. A high neutrophil-lymphocyte ratio (NLR) was a prognostic factor for poor progression-free survival and overall survival (OS) in both univariate and multivariate analyses. In addition, a low hemoglobin (Hb) level and a high systemic immune-inflammation index (SII) were prognostic factors of poor OS in univariate analysis. Hb level was a prognostic factor of OS in both ARPI-naive and ARPI-treated patients. However, a high NLR and SII were only associated with a poor prognosis in ARPI-naive but not in ARPI-treated patients. Hb, NLR, and SII have been suggested to be prognosticators in docetaxel-treated CRPC patients. The differential prognostic value of NLR and SII between ARPI-naive and ARPI-treated patients may require caution when using these markers in docetaxel-treated CRPC patients.

关键词： Thermomicroscopy   DSC   Thermochromic   3D printer filament   Hot-stage microscopy  

摘要： A simultaneous DSC-thermomicroscopy system (DSC450 Linkam Scientific) was applied to the study of phase transitions in rubidium nitrate and silver iodide, the oxidation of polyethylene, the thermal degradation of polylactic acid and magnesium nitrate hexahydrate, and the reversible transitions in thermochromic inks. The results demonstrated the benefits of obtaining simultaneous optical data, both images and light intensity measurements, with DSC, particularly in the interpretation of complex processes and the detection of events with small changes in enthalpy.

关键词： high‐   frequency ultrasound   machine learning   melanocytic naevi   melanoma   ultrasonography  

摘要： Malignant melanoma (MM) is one of the most dangerous skin cancers. The aim of this study was to present a potential new method for the differential diagnosis of MM from melanocytic naevi (MN). We examined 20 MM and 19 MN with a new ultra-high-frequency ultrasound (UHFUS) equipped with a 70 MHz linear probe. Ultrasonographic images were processed for calculating 8 morphological parameters (area, perimeter, circularity, area ratio, standard deviation of normalized radial range, roughness index, overlap ratio and normalized residual mean square value) and 122 texture parameters. Colour Doppler images were used to evaluate the vascularization. Features reduction was implemented by means of principal component analysis (PCA), and 23 classification algorithms were tested on the reduced features using histological response as ground-truth. Best results were obtained using only the first component of the PCA and the weighted k-nearest neighbour classifier;this combination led to an accuracy of 76.9%, area under the ROC curve of 83%, sensitivity of 84% and specificity of 70%. The histological analysis still remains the gold-standard, but the UHFUS images processing using a machine learning approach could represent a new non-invasive approach.

关键词： Calcifying odontogenic cyst   Adenomatoid odontogenic tumor   Computed tomography   Imaging finding  

摘要： Objectives Calcifying odontogenic cysts (COC) and adenomatoid odontogenic tumors (AOT) have similar radiographic findings. We examined the radiographic and computed tomography (CT) images of patients histologically diagnosed with COC or AOT and identified their characteristic findings. Methods The subjects included 12 patients histologically diagnosed with COC or AOT (one female and five males per group), who underwent CT at our hospital between Nov 1998 and Jun 2019. The location of the lesion, impacted tooth, bone expansion, root resorption, tooth migration, calcified body, and presence or absence of a high-intensity zone in the marginal area of the lesion were examined. Results In patients with COC, five patients with COC exhibited bone expansion toward the buccal side. The lesion encompassing the crown was attached to the cement-enamel junction and contained a radiopaque lesion with a calcified body. In 6 patients with COC, irregularly shaped calcified bodies were observed with small tooth-like structures. In patients with AOT, all six patients with AOT exhibited bone expansion toward the buccal and lingual sides. The lesion encompasses a part of the tooth root or the entire tooth. Punctate calcification was observed within the lesion and the marginal area in three patients, and a high-intensity zone was observed in the marginal area of the lesion in two patients. Conclusion We report imaging findings that may be characteristic of COC and AOT, suggesting that CT findings may be useful for differentiating between COC and AOT.

关键词： Differential scanning calorimetry   Baseline subtraction   Automatic signal detection   Peak recognition  

摘要： Differential scanning calorimetry (DSC) is a powerful technique to study temperature induced phase transitions by monitoring the heat capacity changes. Traditional ways of DSC data analysis require manual baseline subtraction and peak analysis, which inevitably leads to errors caused by human bias. To tackle this long-standing challenge, we propose an automated method for DSC signal extraction and baseline estimation based on semi supervised machine learning. We implement an exponential modified Gaussian mixture (EMGM) model to identify the signal of interest, and use the expectation-maximization algorithm to optimize the log-likelihood of the model. This method is then combined with the iterative polynomial fitting method for baseline allocation. One advantage of the method is not requiring the knowledge of the signal, as it is learned through matrix factorization. We demonstrate the method's efficacy using three types of protein data measured by distinctive DSC instruments. It can effectively identify the signals of interest from the raw signal and perform proper baseline subtraction. Furthermore, the program can accurately obtain the thermodynamic parameters from the peak signals for thermal characterization. In summary, this work's automated signal processing method improves the speed and accuracy of the DSC data interpretation. The code and data for this work can be found at: https://g ***/shuyu-wang/DSC_data_analysis/.

关键词： Current mode analog building block (CMABB)   Plus type differential difference current conveyor (DDCC plus )   nth order voltage-mode filter   Current-mode universal filter  

摘要： A general topology for realizing nth order voltage-mode universal filter responses with multiple-input and single-output using only plus type differential difference current conveyor (DDCC +) is presented in this paper. The proposed nth order filter circuit is implemented with n number of DDCC + s, n number of capacitors, and n number of resistors. All the five filter responses, namely low-pass, high-pass, band-pass, band-stop, and all-pass, can be realized simultaneously for both odd and even order of filter with the same generalized topology. The proposed circuit offers the following advantages: the circuit uses only plus-type of DDCC, no critical matching constraints on passive and active elements, universality properties, no requirement to change the hardware for the realization of odd and even order of the filter, fully cascadable, components used are canonical in the count, use of all grounded resistors except one, and the use of only grounded capacitors. Simulations are performed for the third and fourth order of the universal filter to check the various results and responses using PSPICE 180 nm CMOS TSMC technology parameters. The simulated results agree well with the theoretical predictions. The third-order and the fourth-order filter circuits consume low power, 143 mu W, and 189 mu W, respectively. Finally, the paper concludes with the comparison of various parameters with the earlier implementations.