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关键词： Hydrothermal physiology   Thermal performance curves   Climate warming   Tropical amphibians   Direct development frogs   Climate vulnerability   Intraspecific variation  

摘要： In Puerto Rico, an island threatened by climate warming, only one of two species of frogs that share part of their distribution has undergone a recent range contraction to higher elevations. We questioned if differences in their physiological response to temperature and dehydration might explain this distributional change. We studied a lowland and a highland population of Eleutherodactylus coqui, a widespread generalist, and E. portoricensis, an endangered species that is currently found only above 600 m. We compared various physiological aspects: operative temperature;temperature selection;critical temperatures;and their response to jumping performance tests at various thermal and hydric regimes. Results revealed that E. portoricensis had the highest CTmin and lowest CTmax and selected a cooler range of temperatures from the experimental gradient. Jumping performance increased with temperature for the three populations until attaining maximum performance. Afterwards, performance dropped drastically until reaching CTmax. Dehydration had a negative effect on performance for both species, particularly on maximum performance. This effect was greatest for E. portoricensis, followed by highelevation E. coqui. The significantly greater thermo-hydric physiological limitations of E. portoricensis may explain its recent range contraction, potentially, as a response to climate warming. Low-elevation E. coqui had the lowest operative warming tolerance and was the only population to select temperatures like those encountered in their environment, indicating it may be narrowly adapted to local thermal conditions and thus, also vulnerable to climate change. Our results point towards plasticity in the response of E. coqui to varying climatic conditions, and present evidence of different physiological responses between closely related species at the same locality. This work highlights the importance of studying the combined effects of temperature and hydration to understand the res

关键词： cancer   comparative-effectiveness analysis   imaging assessment timing   measurement bias   progression-free survival (PFS)   real-word data (RWD)   scan timing   simulation modeling  

摘要： Background Comparative-effectiveness studies using real-world data (RWD) can be susceptible to surveillance bias. In solid tumor oncology studies, analyses of endpoints such as progression-free survival (PFS) are based on progression events detected by imaging assessments. This study aimed to evaluate the potential bias introduced by differential imaging assessment frequency when using electronic health record (EHR)-derived data to investigate the comparative effectiveness of cancer therapies. Methods Using a nationwide de-identified EHR-derived database, we first analyzed imaging assessment frequency patterns in patients diagnosed with advanced non-small cell lung cancer (aNSCLC). We used those RWD inputs to develop a discrete event simulation model of two treatments where disease progression was the outcome and PFS was the endpoint. Using this model, we induced bias with differential imaging assessment timing and quantified its effect on observed versus true treatment effectiveness. We assessed percent bias in the estimated hazard ratio (HR). Results The frequency of assessments differed by cancer treatment types. In simulated comparative-effectiveness studies, PFS HRs estimated using real-world imaging assessment frequencies differed from the true HR by less than 10% in all scenarios (range: 0.4% to -9.6%). The greatest risk of biased effect estimates was found comparing treatments with widely different imaging frequencies, most exaggerated in disease settings where time to progression is very short. Conclusions This study provided evidence that the frequency of imaging assessments to detect disease progression can differ by treatment type in real-world patients with cancer and may induce some bias in comparative-effectiveness studies in some situations.

关键词： bordering   civil society   refugees   differential inclusion   exclusion   London  

摘要： Taking London as the research context, this article aims to explore the positioning of civil society actors in bordering the differential inclusion/exclusion of asylum seekers and refugees. To do this, and understanding borders/bordering as spaces and social institutions, the article investigates the ways in which civil society actors intervene against bordering, with a particular focus on the labour market and housing. The empirical analysis illustrates that civil society actors seek to open up new spaces of inclusion and new subject positions for refugees and asylum seekers other than those imposed by established bordering processes. However, the capacity of civil society actors to contest the differential inclusion/exclusion enacted in bordering remains limited in the face of constraints produced by neoliberalization and existing political dynamics. More importantly, civil society actors are likely to align themselves with established bordering processes and structures, thus reproducing the differential exclusion/inclusion of asylum seekers and refugees.

摘要： The peritoneum is a unique serosal membrane, which can be the site of primary tumors and, more commonly, secondary pathologic processes. Peritoneal carcinomatosis is the most common malignant condition to affect the peritoneal cavity, and the radiologist plays an important role in making the diagnosis and assessing the extent of disease, especially in sites that may hinder surgery. In this review, we address the role of the radiologist in the setting of peritoneal pathology, focusing on peritoneal carcinomatosis as this is the predominant malignant process, followed by revising typical imaging findings that can guide the differential diagnosis. We review the most frequent primary and secondary peritoneal tumor and tumor-like lesions, proposing a systemic approach based on clinical history and morphological appearance, namely distinguishing predominantly cystic from solid lesions, both solitary and multiple.

关键词： Highly active antiretroviral therapy   duration of HAART therapy   HIV   real-world study   CD4 and CD8 count   immunological response  

摘要： Background: The efficacy of highly active antiretroviral therapy (HAART) can be estimated by the immunological response and the incidence of opportunistic infections. Objective: This study aimed at evaluating the effectiveness of different durations of HAART in terms of immunological response markers (CD4 count and CD4/CD8 ratio) along with disease progression markers (incidence of oral lesions) in Chinese patients with HIV. Methods: This single-center, retrospective, and real-world study included patients with HIV, grouped into a treatment group and treatment-naive group, of which the former was further divided into 6, 12, and 18 months based on the treatment duration. The CD4 and CD8 cell counts were analyzed by the FACSCalibur flow cytometry. Kruskal-Wallis test was applied to determine the outcome of different duration of HAART. Oral examination was carried out according to the WHO type IV examination. Results: In 246 patients with HIV, CD4 counts increased significantly post-HAART compared to pre-HAART in all three treatment groups (P<.001), while CD8 count decreased significantly (P<.05) in all three treated groups. A significant association of HAART with the CD4/CD8 ratio was observed (P<.001). A significant increase in CD4 count was observed between 12-months and 18-months treatment groups (P<.05). The occurrence of oral lesions reduced significantly in the treatment group. Conclusion: We observed a better response to the HAART regimen with 18-months of duration than 12-months and 6-months therapies and reduction in oral lesions.

关键词： Mathematics  

ISBN: (数字)9781800612693 ISBN: (纸本)9781800612686

摘要： The Qualitative Theory of Ordinary Differential Equations (ODEs) occupies a rather special position both in Applied and Theoretical Mathematics. On the one hand, it is a continuation of the standard course on ODEs. On the other hand, it is an introduction to Dynamical Systems, one of the main mathematical disciplines in recent decades. Moreover, it turns out to be very useful for graduates when they encounter differential equations in their work; usually those equations are very complicated and cannot be solved by standard *** main idea of the qualitative analysis of differential equations is to be able to say something about the behavior of solutions of the equations, without solving them explicitly. Therefore, in the first place such properties like the stability of solutions stand out. It is the stability with respect to changes in the initial conditions of the problem. Note that, even with the numerical approach to differential equations, all calculations are subject to a certain inevitable error. Therefore, it is desirable that the asymptotic behavior of the solutions is insensitive to perturbations of the initial *** chapter contains a series of problems (with varying degrees of difficulty) and a self-respecting student should solve them. This book is based on Raul Murillo's translation of Henryk Żołądek's lecture notes, which were in Polish and edited in the portal Matematyka Stosowana (Applied Mathematics) in the University of Warsaw.

关键词： Nonlinear distortion   Cameras   Optical distortion   Standards   Geometry   Three-dimensional displays   Mathematical models   Relative pose   radial distortion   MLE   inliers  

摘要： In this letter, we address the differential two-view geometry problem of estimating the relative pose between two consecutive frames in the presence of radial distortion. This problem is of both theoretical and practical interests and has not been solved. We derive its parameterization and present an effective and robust generalized eigenvalue solver based on the hidden variable technique. Furthermore, we propose a nonlinear refinement scheme within the maximum likelihood criterion to produce more accurate estimates of the relative pose and radial distortion. Compared with the standard differential solutions without modeling the radial distortion, our approach can recover more geometrically correct point correspondences for a pair of radially distorted images. Moreover, our differential solution runs an order of magnitude faster than the discrete solution in terms of recovering the full camera motion. Experiment results on both synthetic and real data demonstrate the effectiveness of our model and method in dealing with the radial distortion.

关键词： Kalman filters   Inrush current   Circuit faults   Surge protection   Harmonic analysis   Power harmonic filters   Current transformers   Differential protection   magnetization current   power transformer  

摘要： Owing to the large magnitude of the inrush currents, the functionality of differential protection of power transformer may be threatened in correct discrimination between inrush and internal faults. This article enhances the functionality of differential protection through a computationally efficient method that utilizes the phase angle current signals of the current transformers (CTs). The proposed discrimination criterion (PDC) tracks the fundamental phase angle of the current signals of the CTs. While during an internal fault, the phase angles of both CTs are almost constant and in phase, during the external fault and inrush currents, the phase angles of both CTs have notable distance. On this ground, this article employs a developed Kalman filter (KF)-based phase angle estimator to measure the fundamental phase angles of the current signals of the CTs. Afterward, PDC is introduced that measures the distance between the estimated phase angles of the CT's currents. Evaluating the effectiveness of the PDC with several simulated and experimental recorded current signals reveals the PDC is able to detect internal faults even in the presence of CT saturation and also to deal with inrush and external fault currents.