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关键词： Amines  

摘要： A 2D/2D NiCo-MOF/Ti3C2 heterojunction is constructed as a non-enzymatic biosensor for the simultaneous electrochemical detection of acetaminophen (AP), dopamine (DA), and uric acid (UA) via differential pulse voltammetry. Benefiting from the synergistic effects of the high electrocatalytic activity of NiCo-MOF, the outstanding conductivity of Ti3C2, and the improved specific surface area of NiCo-MOF/Ti3C2, NiCo-MOF/Ti3C2 displays high sensing performance toward AP (0.01-400 mu M), DA (0.01-300 mu M), and UA (0.01-350 mu M) in 0.1 M phosphate buffer (PB, pH 7.4) at working potentials of 0.346 V vs. SCE for AP, 0.138 V vs. SCE for DA, and 0.266 V vs. SCE for UA. Furthermore, the well-separated oxidation peak potentials allow for the simultaneous detection of the analytes, with detection limits of 0.008, 0.004, and 0.006 mu M (S/N = 3), respectively. As a result of its considerable reproducibility and anti-interference and anti-fouling properties, NiCo-MOF/Ti3C2 was also developed into a practical sensing platform to detect AP, DA, and UA in serum and urine, presenting excellent recoveries of 98.1-102.2 %.

关键词： Non-small-cell lung cancer   Prognostic markers   Biomedicine   general   Cancer Research   Epidemiology   Molecular Medicine   Oncology   Drug Resistance  

摘要： Background Patients with non-small cell lung cancer (NSCLC) receiving curative surgery have a risk of relapse, and adjuvant treatments only translate into a 5% increase in 5-year survival. We assessed the clinical significance of epithelial-mesenchymal transition (EMT) and explored its association with the [SNAIL/miR-34]:[ZEB/miR-200] regulation hub to refine prognostic information. Methods We validated a 7-gene EMT score using a consecutive series of 176 resected NSCLC. We quantified EMT transcription factors, microRNAs (miRs) of the miR-200, miR-34 families and miR-200 promoter hypermethylation to identify outcome predictors. Results Most tumours presented with an EMT-hybrid state and the EMT score was not predictive of outcome. Individually, all miR-200 were inversely associated with the EMT score, but only chromosome-1 miRs, miR-200a, b, 429, were associated with disease-free survival (p = 0.08, 0.05 and 0.025) and overall survival (p = 0.013, 0.003 and 0.006). We validated these associations on The Cancer Genome Atlas data. Tumour unsupervised clustering based on miR expression identified two good prognostic groups, unrelated to the EMT score, suggesting that miR profiling may have an important clinical value. Conclusion miR-200 family members do not have similar predictive value. Core EMT-miR, regulators and not EMT itself, identify NSCLC patients with a low risk of relapse after surgery.

关键词： acute coronary syndrome   drug-eluting stent(s)   percutaneous coronary intervention   ultrathin-strut  

摘要： OBJECTIVES The authors sought to compare the differential effects of ultrathin-strut and thicker-strut drug-eluting stents (DES) in patients with chronic (CCS) versus acute (ACS) coronary syndromes. BACKGROUND Newest-generation ultrathin-strut DES reduce target lesion failure (TLF) compared with thicker-strut second-generation DES in patients undergoing percutaneous coronary intervention. METHODS PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched for randomized controlled trials comparing newer-generation ultrathin-strut (<70 mm) versus thicker-strut (>= 70 mm) DES. Patients were divided based on baseline clinical presentation (CCS versus ACS). The primary endpoint was TLF, a composite of cardiac death, target vessel myocardial infarction, or clinically indicated target lesion revascularization (TLR). RESULTS A total of 22,766 patients from 16 randomized controlled trials were included, of which 9 trials reported TLF rates in ACS patients. At a mean follow-up of 12.2 months, the risk of TLF was lower among patients treated with ultrathin-strut compared with thicker-strut DES (risk ratio [RR]: 0.85;95% CI: 0.75-0.95;P = 0.006). The difference was driven by a lower risk of clinically-indicated TLR (RR: 0.75;95% CI: 0.63-0.89;P < 0.001) among patients treated with ultrathin-strut DES. The treatment effect was consistent between patients presenting with CCS and ACS (relative RR: 0.97;95% CI: 0.73-1.31;P for interaction = 0.854). In patients with ST-segment elevation myocardial infarction, TLF risk was lower among those treated with ultrathin- compared with thicker-strut DES (RR: 0.74;95% CI: 0.54-0.99;P = 0.049). CONCLUSIONS Ultrathin-strut DES reduce the risk of TLF compared with thicker-strut second-generation DES in patients undergoing percutaneous coronary intervention, a difference caused by a lower risk of ischemia-driven TLR. The treatment effect was consistent among patients with CCS and ACS. (C) 2021 The Authors. Published by Elsev